ISHI 2009, Las Vegas
Dr. Kevin McElfresh delivered a presentation at the 20th International Symposium on Human Identification “The Real Deal” sponsored by Promega held in Las Vegas, Nevada October 12-15, 2009.
Abstract: In 20 years the amount of DNA required for a DNA test has decreased from micrograms to nanograms, the time required has decreased from weeks to hours, and the acceptance of the technology from skeptical to fundamental. However one of the remaining persistent problems is the interpretation of mixtures, that is, multiple individuals within a single sample. We show that by applying GWAs based analysis methods to forensic samples it is possible to resolve individuals within complex mixtures, as well as address other challenging forensic sample types such as in highly degraded samples. Our technology utilizes the cumulative statistical power from genotyping hundreds of thousands of SNPs to analyze single source forensic samples as well as complex mixtures. The data show that it is possible to parse a mixture of a few individuals using as few as several thousand SNPs and mixtures of hundreds of individuals using 300,000 or more SNPs.
Work presented is proprietary and patent pending.
See Dr. Kevin McElfresh's Presentation "Utilizing 300,000 or More Single Nucleotide Polymorphisms
for the Identification of Individuals Within a Forensic Mixture" here. |